Synthesis and Characterization of Two Sustained Release Systems of Micro- and Nano-sized Particles for Controlled Release of Atorvastatin for Bone Tissue Engineering Applications
نویسندگان
1 Biomaterial Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran
2 Amirkabir University of Technology, NO 350, Hafex Street, Valiasr Square, Tehran, Iran
3 Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
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چکیده
Aims: Using osteoinductive agents in combination with tissue engineering scaffolds is considered as a new approach to bone repair. Recently, statins have attracted great attention among a variety of drugs used in bone repair. In order to achieve a sustained release of Atorvastatin from bone scaffolds, two systems, including nanoniosomes and gelatin microspheres, were synthesized and compared. Materials and Methods: Nanoniosomes and gelatin microspheres were prepared by thin-film hydration and single emulsion technique, respectively. Findings: The prepared systems were characterized for morphology, size, carriers’ preparation efficiency, encapsulation efficiency, and drug loading. Also, release profiles of them were evaluated over a period of one week. The results indicated the formation of relatively spherical niosomes with the diameter of about 653.52nm and encapsulation efficiency of 81.34%, and formation of gelatin microspheres with the diameter of about 37.5μm and the encapsulation efficiency of 78.93%. Conclusion: The results showed that gelatin microspheres had a lower burst release than niosomes, and niosomes had more sustained release than gelatin microspheres after 24hr to 1 week. Albeit, selection of the optimal system requires cellular studies and also the selection must occur according to the severity of the damage and the rate of repair.
