Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer
نویسندگان
1 Department of Immunology and Cancer Research Center
2 Department of Surgery, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz
3 Department of Immunology and Cancer Research Center
4 Department of Immunology, Faculty of Medicine
5 Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
6 Department of Immunology and Cancer Research Center
doi
10.22034/iji.2013.16800چکیده
Background: Regulatory T cells (T-regs) have an important role in cancer by suppression of protective antitumor immune responses. Regulatory T cells express the forkhead/winged helix transcription factor (FOXP3) and OX40 molecules which have important regulatory roles in the immune system. Objective: To evaluate FOXP3 and OX40 transcripts in the peripheral blood mononuclear cells of women with breast cancer. Methods: Blood samples from 40 women with histologically-confirmed infiltrating ductal carcinoma of the breast and 40 healthy volunteer women without a history of malignancy or autoimmune disorders were collected. The abundance of FOXP3 and OX40 gene transcripts were determined by quantitative real-time PCR (qRT-PCR). Results: There was a significant positive correlation between FOXP3 and OX40 gene expression in women with breast cancer in a stage dependent manner. Conclusion: This finding emphasizes the importance of T-regs as predominant targets for breast cancer immunotherapy.
