Concerns Regarding the Efficacy of Utilizing the Vibrational Response of Aminocyanine Molecules to Near Infrared Light for Cancer Cell Destruction
نویسندگان
1 Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5 Department of Radiation Oncology, Stritch School of Medicine Loyola University Chicago, Maywood, IL, USA
6 Department of Radiation Oncology, Edward Hines Jr Veterans Affairs Hospital, Maywood, Illinois, USA
7 MVLS College, The University of Glasgow, Glasgow, Scotland, United Kingdom
8 Department of Medical Imaging, School of Allied health Sciences, University for Development Studies, Ghana
9 Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
doi
10.31661/jbpe.v0i0.2408-1806چکیده
Recent advancements in cancer treatment have introduced the use of aminocyanine molecules, activated by near-infrared (NIR) light, to induce vibrational responses that can selectively destroy cancer cells. This commentary critically examines a study that reports a 99% efficacy of this method against human melanoma cells in vitro, and significant tumor reduction in murine models. While the findings are promising, our analysis highlights crucial oversights in the study’s implications for clinical applications. Specifically, the persistence of even a small fraction of cancer cells post-treatment poses significant risks for tumor regrowth and acquired resistance. Additionally, the study’s approach neglects the heterogeneity of cancer cells and the presence of cancer stem cells, which are known to contribute to recurrence and resistance. We also discuss the limitations of the Tumor Control Probability (TCP) model in predicting treatment outcomes, emphasizing that achieving near-total eradication of cancer cells is necessary to prevent recurrence. Our commentary underscores the need for comprehensive research to address these challenges and ensure the efficacy and safety of novel cancer treatments utilizing aminocyanine molecules and NIR light.
