Determining Appendectomy Based on Different Mutations inPatients with Familial Mediterranean Fever Under 18 Years Old
نویسندگان
1 Assistant Professor of Pediatric Hematology and Oncology, Pediatrics Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
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3 Assistant Professor of Pediatric Rheumatology, Pediatric Diseases Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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چکیده
Background and Objective: Genetic mutations in Familial Mediterranean Fever (FMF) directly causeinflammation and activation of the body's immune system. These inflammations often occur in various areasof the body, including the abdomen, and may resemble symptoms of appendicitis. In many cases, theseabdominal inflammations recur, and at times, it can be challenging for physicians to determine whether theinflammation is due to appendicitis or FMF. Therefore, the present study was conducted to address this gapand aimed to determine the correlation between the type of mutations and the decision to performappendectomy in patients under 18 years old with FMF.Materials & Methods: This descriptive cross-sectional study was conducted at Ardabil University ofMedical Sciences, involving patients with Familial Mediterranean Fever who presented to the emergencydepartment of Kowsar Hospital in Ardabil. Data were collected from the clinical records of the patients andsystematically analyzed. Between March 2023 and September 2024, 120 patients under 18 years old whovisited the emergency department were included in the study. Information regarding age, gender, type ofmutation, and previous surgical history was collected, and the relationships between demographic andclinical variables with treatment outcomes were assessed.Results: Among the 120 patients with FMF, only 14 (11.67%) underwent appendectomy. The patientswere divided into two groups based on whether they had undergone appendectomy or not, and thefrequency of appendectomy was compared according to the type of genetic mutation. The results showed nosignificant difference between the two groups regarding the type of mutation (P=0.7), meaning that differentmutations did not influence the decision to perform appendectomy in these patients.Conclusion: This study concludes that in patients with Familial Mediterranean Fever, different geneticmutations do not have a significant impact on the decision to perform appendectomy. These findingshighlight the importance of considering other clinical factors, such as medical history, immune status, andclinical signs, when making treatment decisions.
