Synthesis of Pyrimidine-Based Analogues: A Comprehensive Review
نویسندگان
1 Department of Chemistry, M.S. Ramaiah Institute of Technology (Autonomous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India
2 Department of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia
3 Department of Chemical Engineering, M.S. Ramaiah Institute of Technology (Autonomous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India
4 Department of Chemistry, M.S. Ramaiah Institute of Technology (Autonomous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India
5 Department of Chemistry, M.S. Ramaiah Institute of Technology (Autonomous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India
6 Department of Chemical Engineering, M.S. Ramaiah Institute of Technology (Autonomous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India
7 MLR Institute of Technology, Laxman Reddy Avenue, Dundigal, Hyderabad, Telangana 500043, India
8 Department of Chemistry, M.S. Ramaiah Institute of Technology (Autonomous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India
9 Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510, India
doi
10.48309/jcr.2025.516643.1438چکیده
Pyrimidine constitutes a diverse category among various heterocyclic compounds with broad-ranging applications in medicinal chemistry and agriculture. In recent years, for the advancement of novel synthetic techniques for the efficient synthesis of various pyrimidine-based compounds, substantial studies were done. This review article provides a comprehensive overview on the latest advancements (2020-2024) in the synthesis of pyrimidine analogues, by focusing on essential strategies, and practical applications. The review commences by highlighting the crucial role of pyrimidine analogues in pharmaceutical research and development. It goes on to explore various techniques for the synthesis of pyrimidine analogues encompassing both traditional and contemporary pathways. The latest approaches mainly focus on developing techniques that are eco-friendly and sustainable along with the incorporation of computational tools and catalysis to streamline the synthesis.
