Polymeric Drug Delivery Systems: Chemical Design, Functionalization, and Biomedical Applications
نویسندگان
1 Department of Pharmaceutical Chemistry, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Sasaram (Rohtas) Bihar - 821305, India
2 School of pharmacy, Ushamartin University, Ranchi, Jharkhand, India
3 Department of Pharmacology, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Medchal, Hyderabad, Telangana - 500 088, India
4 Deportment of pharmaceutics, School of pharmacy, Anurag University, Hyderabad, Telangana,500088, India
5 Department of Pharmacology, Dadhichi college of pharmacy, Cuttack, Sundargram, Odisha 754002, India
6 Department of Pharmaceutics, Vishnu institute of pharmaceutical education and research, narsapur, Telangana, India
7 Faculty of Pharmaceutical Sciences, Amrapali University, Haldwani, Uttarakhand 263139, India
8 Apex Institute of Pharmacy, Education and Research Raigarh, Chhattisgarh, India
9 Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India
doi
10.48309/jcr.2025.516027.1435چکیده
Polymeric drug delivery systems are emerging as versatile and efficient platforms for controlled and systematic release of drugs for treatment. These approaches reduce systemic toxicity and adverse effects by enhancing pharmaceutical stability, increasing bioavailability, and enabling targeted drug administration. This study comprehensively presents the chemical design, functionalization processes, and biological applications of polymeric drug carriers. The performance of these systems is impacted by the choice of polymers, their biodegradability, and their synthesis techniques. Furthermore, enhanced functionalization methods, including surface modifications, stimuli-responsive characteristics, and ligand conjugation, are gaining relevance in precision medicine. Polymeric drug delivery technologies show great promise in cancer treatment, neurological diseases, infectious disease treatment, tissue engineering, and gene delivery. Notwithstanding these developments, issues such as biocompatibility, large-scale manufacturing, and regulatory concerns must be resolved to allow for broad clinical translation. Emphasizing the transforming power of polymer-based drug delivery to enhance therapeutic results, this review discusses recent advancements, present constraints, and prospects in the sector.
