Chemistry, Molecular Mechanisms, and Therapeutic Potential of Curcumin in Cancer Therapy
نویسندگان
1 Department of Pharmaceutical Chemistry, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Sasaram (Rohtas) Bihar - 821305, India
2 Department of Pharmacognosy and Phytochemistry, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, India
3 Department of Pharmacology, School of Pharmacy and life Sciences, Centurion University of Technology and Management, Bolangir, 767001, Odisha, India
4 Department of Pharmaceutical Chemistry, N.B.S. Institute of Pharmacy, Ausa, Latur, Maharashtra, India
5 Department of Pharmaceutical chemistry Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University) Karad, Maharashtra 415539, India
6 Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh, India
7 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah 51452, Saudi Arabia
8 Department of Pharmacology, Dr Rajendra Gode College of Pharmacy, Malkapur, Maharashtra, 443101, India
doi
10.48309/jcr.2025.516636.1437چکیده
In recent years, a major focus has been placed on curcumin, a naturally occurring polyphenolic substance derived from Curcuma longa L., for its potential clinical benefits in enhacing cancer-targeted therapy. This extensive clinical study provides a methodical evaluation of the various functions and mechanisms of curcumin in improving cancer-targeted therapy and discusses its potential use in cancer treatment. Curcumin, the primary active compound in turmeric, exhibits antioxidant, anticancer, and anti-inflammatory properties. Curcumin, an essential ingredient of the spice turmeric, is an alternative strategy for cancer prevention. Janus-kinase/signal transducers and activators of transcription (JAK/STAT), Nuclear Factor-kappa B (NF-κB), and transforming growth factor-β (TGF-β) pathways are just a few of the signalling pathways altered by curcumin in cancer cells. The potential for specific treatment approaches is highlighted by the prospect of curcumin as a secondary drug in cancer-targeted therapy. This study outlines ongoing clinical trails and novel formulations developed to enhance curcumin's bioavailability and efficacy, which could pave the way for more extensive use of the compound in cancer treatment. Further research and clinical investigations are necessary to elucidate the full therapeutic potential of this natural compound against cancer.
