Advances in Stimuli-Responsive Polymers: Design Strategies, Synthesis Methods, and Emerging Nanotechnology Applications
نویسندگان
1 Department of Pharmaceutics, Arulmigu Kalasalingam College of pharmacy, TN Dr. MGR Medical University, krishnankoil, Tamil Nadu-626126, India
2 School of pharmacy, Ushamartin University, Ranchi, Jharkhand, India
3 Raghu college of pharmacy, Dakamarri, Bhimunipatnam, Vishakapatnam 531162, India
4 School of Pharmacy, Anurag University, Venkatapur, Ghatkesar Rd, Hyderabad Telangana-500088, India
5 Deportment of pharmaceutics, School of pharmacy, Anurag University, Hyderabad, Telangana,500088, India
6 Department of Plant Pathology, School of Agriculture, Lovely Professional University, Jalandhar, Punjab, India
7 Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India
8 Pharmaceutics Division, College of Pharmaceutical Sciences, Dayananda Sagar University, Harohalli, Bengaluru – 562 112, India
doi
10.48309/jcr.2025.509041.1418چکیده
Stimuli-responsive polymers (SRPs) or smart polymers have attracted considerable interest in nanotechnology because of their capacity to undergo regulated physicochemical changes in response to external stimuli. This study offers an extensive examination of the current advancements in their design, synthesis, and applications. These polymers are classified according to their response to physical stimuli (temperature, pH, light, magnetic fields, and electric fields), chemical stimuli (redox, enzymatic, and ionic), and multi-stimuli-responsive systems. Various synthesis strategies, including controlled/living polymerization, graft and block copolymerization, functionalization approaches, and green synthesis methods, have been explored to enhance structural and functional versatility. The application of these polymers in nanotechnology has revolutionized fields, such as drug delivery, biosensors, tissue engineering, self-healing materials, and smart nano-electronics. Their potential in biomedical applications is particularly promising as they offer controlled drug release, real-time diagnostics, and advanced regenerative medicine solutions. However, challenges, such as long-term stability, scalability, reproducibility, and biocompatibility, should be addressed to ensure their widespread adoption. Future research is directed towards developing advanced polymer architectures with enhanced sensitivity, biocompatibility, and multi-functionality. This review highlights the emerging trends and transformative potential of SRPs for advancing next-generation nanotechnologies.
