Recent Advances in Medicinal Chemistry with Benzothiazole-Based Compounds: An In-Depth Review
نویسندگان
1 Navin Fluorine International Ltd, Dewas, Madhya Pradesh, 455111, India
2 St.Joseph Vaz College, Cortalim Goa, 403710, India
3 Department of Chemistry, Shivaneri Mahavidyalaya Shirur Anantpal, Dist-Latur, 413544, India
4 Department of Chemistry, K. M. C. College, Khopoli, Dist. Raigad, 410203, India
5 Department of Chemistry, Kai. Rasika Mahavidyalaya Deoni, Dist-Latur, Maharashtra, 413519, India
6 Department of Chemistry, Shivaji Mahavidyalaya, Renapur, Dist. Latur, 413527, India
7 Department of Chemistry, Shri Kumarswami Mahavidyalaya, Ausa Dist Latur, 413520, India
8 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, Latur, Dist Latur, 413512, India
doi
10.48309/jcr.2024.436111.1290چکیده
Among the many natural ingredients and pharmacological drugs that contain heterocyclic compounds, benzothiazole (BTA), and its derivatives stand out as particularly significant. BTA analogs provide a great deal of structural diversity, which has been helpful in the quest for new therapeutic drugs, and BTA itself displays a variety of pharmacological features. Because each BTA derivative has its own unique set of pharmacological effects, it is clear that this class of chemicals is intriguing. Medicinal chemistry based on BTAs is a hot subject right now, with lots of new research and discoveries happening in the field. In particular, there are a plethora of BTA-based compounds that have found widespread clinical use as highly effective medications for a wide range of disorders. Current developments of BTA-based compounds in medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial, and other medicinal agents are presented in this work systematically and thoroughly. More effective diagnostic agents, pathologic probes, and BTA-based medications that are both active and less toxic, can be rationally designed, according to the authors of this review study.
