فهرست نشریات علمی دسترسی آزاد ایران

Background: Inflammation and cytokine storms due to cardiovascular diseases (CD). Herbals can be the primary source of compounds with anti-inflammatory properties. Furthermore, herbals agents may consider as a complementary medicine. Bioactive compounds and phytochemicals have potential strategies to halt or manage CD. flaxseed have antioxidant and anti-inflammatory activity. Methods: In this study, we used H9c2 cell lines of rat embryonic cardiomyocytes. To induce CD we used hyperglycemic and hyperlipidemic conditions. Real-Time-PCR performed to evaluated the relative expression of the genes. Results: We found that flaxseed could decreased the expression level of the IL-1β and NLRP3. Moreover, the expression level of the NRF-1 and Sirt-1 increased by flaxseed. Conclusion: Our data proposed that flaxseed could have potential approaches to manage and prevent CD.