فهرست نشریات علمی دسترسی آزاد ایران

Background: Glioblastoma multiforme (GBM) is an aggressive brain tumor characterized by rapid progression and poor prognosis. This study investigated the effects of resistance training and nano-curcumin supplementation on ATM gene expression and the inflammatory protein S100 in a rat model of C6 glioblastoma. Methods: This study investigated resistance training and nanocurcumin in an orthotopic GBM rat model (n=40), with groups including healthy controls, cancer controls, nanocurcumin (80 mg/kg/day), resistance training (ladder climbing, 50% BW + 30g, 3×/week), and combined intervention. Glioblastoma was induced by stereotaxic injection of C6 cells into the right frontal cortex. Nano-curcumin-loaded chitosan nanoparticles were prepared and administered orally at a dose of 80 mg/kg, while resistance training was conducted using a ladder-climbing protocol three times per week for four weeks. Two-way ANOVA with Bonferroni post hoc tests were used to assess group differences (p < 0.05). Results : Results demonstrated that both resistance training and nano-curcumin independently increased ATM gene expression (p = 0.000), suggesting enhanced DNA repair capacity and genomic stability in tumor tissue, although no significant interaction effect was observed between the two interventions (P = 0.503). Conclusion: These findings suggest that resistance training can modulate tumor progression through dual mechanisms—enhancing genomic repair via ATM upregulation and attenuating inflammatory and stress-related pathways—while nano-curcumin primarily influences genomic stability mechanisms. Overall, the study highlights the efficacy of resistance training as a non-pharmacological intervention to improve antitumor responses and underscores the need for further research to optimize nano-curcumin administration strategies.