فهرست نشریات علمی دسترسی آزاد ایران

Introduction: The present study aimed to investigate the impact of an eight-week swimming training (ST) program combined with cinnamon (Cin) administration on cardiac creatine kinase (CK-MB) and lactate dehydrogenase (LDH) in streptozotocin-induced diabetic rats. Methods: In this experimental study, 32 streptozotocin-induced diabetic rats (55 mg/kg) were randomly assigned to four groups: (1) diabetic control (CD), (2) swimming training (ST), (3) cinnamon supplementation (Cin), and (4) swimming training + cinnamon (ST+Cin). An additional eight rats were allocated to a healthy control group (HC) to examine the effects of diabetes induction on the study variables. Swimming exercise was performed in water maintained at 36 ± 2 °C, five sessions per week for eight weeks, with each session lasting 5–22 minutes. Cinnamon aqueous extract was administered at a dose of 200 mg/kg/day, dissolved in drinking water. Results: Serum CK-MB and LDH levels were significantly lower in ST, Cin, and ST+Cin groups compared with the CD group (p≤0.05). Serum CK-MB concentrations in the Cin group were significantly lower than those in the ST (p=0.013) and ST+Cin (p=0.001) groups. Conversely, LDH levels in the ST (p=0.004) and ST+Cin (p=0.001) groups were significantly lower than in the Cin group. Moreover, LDH concentrations in the ST+Cin group were significantly reduced compared with the ST group (p=0.012). Conclusion: Overall, swimming exercise and cinnamon consumption, both individually and in combination, appear to synergistically reduce cardiac risk factors such as CK-MB and LDH. Notably, cinnamon exerted a more pronounced effect on reducing CK-MB levels compared with exercise alone.