فهرست نشریات علمی دسترسی آزاد ایران

Background: Long non-coding RNAs (LncRNAs) have been implicated in various biological processes and tumorigenesis. PANDAR is one of the long non-coding RNAs implicated in the development of multiple cancers, which has yet to be investigated for its clinical significance in hepatocellular carcinoma (HCC). Therefore, this study aimed to investigate the clinical significance of PANDAR in a cohort of Iranian patients with HCC.Method: In this cross-sectional study, real-time quantitative polymerase chain reaction (PCR) was employed to analyze the expression levels of PANDAR in 22 paired HCC and adjacent normal tissues. Patients were subsequently stratified into high- and low-expression subgroups based on PANDAR expression levels. The associations between PANDAR expression, clinicopathological features, and overall survival were evaluated and analyzed using appropriate statistical tests.Results: The results showed that PANDAR expression was significantly increased in HCC tumor tissues compared with adjacent normal tissues (P = 0.03, fold change = 2.04). Although Kaplan-Meier analysis did not reveal a significant difference in mean overall survival between the high- and low-expression groups (P = 0.215), Cox regression analysis identified an independent predictor role of PANDAR expression in HCC, both in univariate (hazard ratio (HR)=1.74, 95% confidence interval (CI): 1.10-2.99, P = 0.04) and multivariate (HR=1.74, 95%CI: 1.01-3.901, P = 0.05) models.Conclusion: This study suggests that elevated PANDAR expression is associated with poor prognosis in HCC patients, thereby highlighting its potential clinical utility as a promising prognostic biomarker and therapeutic target.