Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study

نویسندگان
Jayachander, Dipika ID 1
Vidyasagar, Mamidipudi Srinivasa ID 2
Lobo, Ashwin DL ID 3
Rao, Suresh ID 4
Baliga, Manjeshwar Shrinath ID 5
Shivashankara, Arnadi Ramachandrayya ID 6
Tonse, Raees ID 7
Pais, Sarita ID 8
Hegde, Sanath Kumar ID 9

1 Department of Radiation Oncology, Apollo Hospital, Bengaluru, Karnataka, India

2 Department of Radiotherapy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India

3 Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India

4 Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India

5 Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India

6 Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India

7 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

8 Department of Radiation Oncology, Narayana Hrudayalaya, Bengaluru, Karnataka, India

9 Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India

doi
10.30476/mejc.2018.42115
چکیده

Background: This study evaluates the predictive significance of salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and neck cancer patients who undergo curative radiotherapy/chemoradiotherapy.Methods: The volunteers for the study included head and neck cancer patients that required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood samples before the start of radiation treatment and 24 h after the first radiation fraction of 2 Gy (before the start of the second fraction). Samples were assessed for the levels of blood and salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase by standard laboratory methods. Clinical tumor radioresponse was assessed one month after the completion of treatment as complete responders, partial responders, and nonresponders.Results: The results indicated a significant increase in the levels of amylase, lactate dehydrogenase, and lipid peroxides; and a concomitant decrease in the levels of glutathione P

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