فهرست نشریات علمی دسترسی آزاد ایران

Background: Pseudomonas aeruginosa is characterized as an important nosocomial pathogen with increasing antimicrobial resistance. The multidrug-resistant (MDR) phenotype in P. aeruginosa is increasing worldwide. The purpose of this study was to evaluate the prevalence of antibiotic susceptibility, ESBLs (Extended spectrum beta lactamases) producing and multidrug resistant (MDR) P. aeruginosa, isolated from clinical specimens of patients and environment of hospital. Results: The highest resistance rates from the isolated P. aeruginosa were shown against piperacillin, imipenem, cefotaxime, ceftriaxone, gentamicin, ceftazidime, aztreonam, and ciprofloxacin, respectively. Seven isolates (9.2%) were ESBL producers. More than 30% of the isolates were resistant to at least three classes of antibiotics, and 13% of MDR strains were resistant to all eight tested classes of antimicrobials. Among the total isolates, 6.6% were susceptible to all studied agents, and 9.2% were resistant to a single agent. The isolated bacteria from the tracheal samples showed the highest MDR rate. Conclusion: Prevalence of P. aeruginosa producing ESBL and MDR strains from our clinical samples and environment is still low.