فهرست نشریات علمی دسترسی آزاد ایران

Background: CTX-M-type β-lactamases are increasingly becoming the predominant ESBLs globally in recent years. Integrons are genetic elements which can integrate gene cassettes, usually antibiotic resistance genes. Objectives: The aims were to determine antibiotic susceptibility and to detect genes encoding CTX-M-1 group enzymes and class 1, 2, and 3 integrons among the Klebsiella pneumoniae isolated from children in Tehran hospitals, Iran. Results: Most of the isolates showed high level of resistance: 17 isolates were simultaneously resistant to Amoxicillin-Clavulanic acid, Cefotaxime, Ceftriaxone, Aztreonam, and Ceftazidime (17/31, 54.9%). All were susceptible to Imipenem and Ciprofloxacin. ESBL production was detected in 54.9% (17/31). The bla CTX-M-1 group was detected in all Cefotaxime-resistant isolates (17/31, 54.9%). Class 1 integron was detected in 8 isolates (25.8%). The class 2 and 3 integrons were not detected. Conclusions: The results showed that the CTX-M-1- producing K. pneumoniae is already present in some parts of Tehran. The presence of class I integron genes among resistant strains of K. pneumoniae highlights the continued monitoring of drug resistance in clinical settings.