فهرست نشریات علمی دسترسی آزاد ایران

Background: Coagulase-negative staphylococci (CoNS) are clinically important, especially in nosocomial and neonatal infections. The increasing emergence of glycopeptide-resistant CoNS has made these agents therapeutically challenging. Objectives: We aimed to investigate the susceptibility patterns of CoNS to teicoplanin and vancomycin in Gorgan, northern Iran. Results: Only 1% of CoNS ( Staphylococcus haominis ) showed resistance to vancomycin and 15% of these were intermediate-resistant to teicoplanin on the disc diffusion agar test. In addition, all isolates (100%) were negative for vanA on PCR and sensitive with E-test methods. The mean MIC value of vancomycin was 1.35 ± 0.29 µg/mL. S. haemolyticus and S. epidermidis showed the highest rates of MDR (50% and 24%, respectively). Additionally, CoNS isolated from blood (42%) and urine samples (30%) had the highest rates of MDR. Conclusions: Vancomycin, but not teicoplanin, can be considered an effective antibiotic of choice for controlling infections caused by MDR CoNS in Gorgan, depending on the bacterial species.