Disseminated Bacille Calmette-Guérin Infection in Immunodeficient Infants: Report of Two Cases

نویسندگان
asghari rokhsareh ID 1
mohit mohsen ID 2
salarbashi davoud ID 3
seifi sima ID 4
marjani abdoljalal ID 5
kahanamani falahati pour sakineh ID 6

1

2 دانشگاه علوم پزشکی شیراز

3

4 دانشگاه علوم پزشکی گلستان

5

6 دانشگاه تهران

doi
10.5812/pedinfect.37490
چکیده

Introduction: The Bacille Calmette-Guérin (BCG), a live attenuated Mycobacterium bovis vaccine, is administered to all the newborns in Tunisia in order to prevent Tuberculosis (TB). Complications of this vaccine are uncommon. However, it poses a risk for children with unknown immunodeficiency. Conclusions: Molecular methods are available to respond to the urgent need for rapid and specific diagnosis of local/regional or systemic BCG disease, using available commercial kits GenoType® MTBC and GenoType® MTBDRplus. These tests allow prevention of inoculation of live vaccines such as BCG among the next siblings until appropriate screening tests exclude primary or secondary immunodeficiency syndromes.

کلیدواژه‌ها
Bacille Calmette-Guérin Vaccine, Mycobacterium bovis, Molecular Diagnostic Techniques, Immunologic Deficiency Syndromes