فهرست نشریات علمی دسترسی آزاد ایران

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to most antibiotics and can transfer resistance to other bacteria, which is a significant problems among hospitalized children with MRSA infections. Objectives: The aim of this study was to detect bla OXA-1 and bla DHA-1 AmpC β-lactamase-producing MRSA in hospitals. Results: From the 56 MRSA samples, the highest antibiotic resistance was to penicillin (92.29%) and ceftazidime (82.98%). All isolates were sensitive to linezolid and vancomycin. Only one clinical MRSA sample carried both bla OXA-1 and bla DHA-1 AmpC β-lactamase-encoding genes Conclusions: Improper consumption of antibiotics and environmental factors play important roles in the emergence and spread of antibiotic-resistant MRSA. Thus, the significance of the isolates from this study was that they were assayed for the presence of resistant genes, such as bla OXA-1 and bla DHA-1 AmpC β-lactamase, in healthcare worker and patient samples, and decolonized to reduce transmission of antibiotic-resistant microorganisms in hospitals.