In Vitro Activity of Two Nanoparticles on Clinical Isolates of Candida parapsilosis, Showing Resistance Against Antifungal Agents in Children

نویسندگان
akhavan rezayat arash ID 1
taghizadeh ghehi maryam ID 2
keymoradzadeh arman ID 3
taremian farhad ID 4
mehmandoust mahdieh ID 5
hashemi rezvan ID 6
bidkhori mohammad ID 7

1 دانشگاه علوم پزشکی شیراز

2

3

4 دانشگاه علوم پزشکی تهران

5 دانشگاه علوم پزشکی تهران

6 دانشگاه علوم پزشکی تهران

7 دانشگاه علوم پزشکی تهران

doi
10.5812/archcid.13853
چکیده

Background: Resistance of pathogenic fungi to conventionally available antifungal agents has been increasing and has become a serious problem. On the other hand, nanoscience has emerged as a powerful tool capable of developing and designing new antimicrobial drugs. Objectives: The aim of this study was to test minimum inhibitory concentrations (MICs) of silver (Ag-NPs) and selenium (Se-NPs) nanoparticles, both alone and in combination with antifungal agents fluconazole (FLU), itraconazole (ITR), and amphotericin B (AMB) on resistant C. parapsilosis strains. Methods: Eight C. parapsilosis strains resistant to antifungal agents (FLU, ITR, AMB) and the standard strain of C. parapsilosis (ATCC 22019) as a control were used in this study. The standard protocol of antifungal susceptibility testing for yeast was performed by the broth micro-dilution method described in the clinical and laboratory standards institute (CLSI) guidelines, document M 27-S4.

کلیدواژه‌ها
Nanoparticles, Fungal Drug Sensitivity Tests, Candida parapsilosis