Is chronic kidney disease, a predictor of in-hospital mortality in Coronavirus Disease 2019 (COVID-19) patients?
نویسندگان
1 Student Research Committee, Vice Chancellor for Research and Technology, Kurdistan University of Medical Sciences, Sanandaj, Iran
2 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Internal Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
5 Epidemiology and Biostatics Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
6 Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
7 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
8 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
9 Department of Internal Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
10 Department of Internal Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
11 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
12 Department of Infectious Disease, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
doi
چکیده
Background: Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 (COVID-19) patients considering its high prevalence. We aimed to figure out the relationship between CKD and COVID-19 mortality in this study.Materials and Methods: In total, 116 CKD patients (estimated glomerular filtration rate [eGFR] lower than 60 mL/min/1.73 m2) and 147 control subjects confirmed with COVID-19 were studied. Data regarding demographics, sign and symptoms, laboratory findings, and chest computed tomography were collected. Association between CKD and in-hospital mortality were analyzed using logistic regression models adjusted for confounders.Results: Mortality rate was significantly higher in CKD than non-CKD (30.17 vs 4.76, P < 0.001) COVID-19 patients. Multivariate logistic regression showed that CKD was significantly correlated with in-hospital mortality in the total sample (Odds ratio (OR) = 8.64, confidence interval (CI): 3.67–20.35) and gender subgroups (females: OR = 4.77, CI: 1.38–16.40, males: OR = 13.43, CI: 3.85–46.87) (P < 0.05) of COVID-19 patients in the crude model. Whereas, the correlation did not remain significant in the fully adjusted model in the total sample (OR = 1.70, CI: 0.35–8.19) and gender subgroups (females: OR = 1.07 CI: 0.06–19.82, males: OR = 0.87, CI: 0.07–10.33) (P > 0.05) of COVID-19 patients.Conclusion: This study suggested an independent association between CKD and in-hospital mortality in COVID-19 patients. Therefore, more intensive surveillance of COVID-19 patients with CKD is to be warranted.
