Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association with Clinical Laboratory Routine Tests

نویسندگان
Ghazanfari, Tooba ID 1
Edalatifard, Maryam ID 2
Salehi, Mohammad Reza ID 3
Raeeskarami, Seyed Reza ID 4
Sattarian, Mohammad Reza ID 5
Najafizadeh, Reza ID 6
Hosseinieselki Sari, Sajjad ID 7
Nezhadseifi, Elham ID 8
Baharvand, Elahe ID 9
Rostamian, Abdolrahman ID 10
Arabkheradmand, Jalil ID 11
Ghaffarpour, Sara ID 12
Mahmoodi Aliabadi, Maedeh ID 13
Rajabnia Chenary, Maryam ID 14
Mirsharif, Ensie Sadat ID 15
Jamali, Davoud ID 16
Jafarpour, Samira ID 17
Movasseghi, Shafieh ID 18
Beiranvand, Saba ID 19
Roomi, Azin ID 20
Naghizadeh, Mohammad Mehdi ID 21

1 Immunoregulation Research Center, Shahed University, Tehran, Iran

2 Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

4 Department of Pediatrics, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

5 Simorgh Clinical Laboratory, Tehran, Iran.

6 Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

7 Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran.

8 Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

9 Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

10 Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

11 Defense Health Research Center, Tehran, Iran.

12 Immunoregulation Research Center, Shahed University, Tehran, Iran

13 Central laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

14 Defense Health Research Center, Tehran, Iran.

15 Immunoregulation Research Center, Shahed University, Tehran, Iran.

16 Department of Immunology, Shahed University, Tehran, Iran.

17 Defense Health Research Center, Tehran, Iran.

18 Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

19 Department of nursing, Islamic Azad University, Tehran, Iran.

20 Department of nursing, Islamic Azad University, Tehran, Iran.

21 Non-communicable Diseases Research Center, Fasa University of Medical Science, Fasa, Iran.

doi
10.32598/Immunoregulation.3.1.4
چکیده

Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by Coronavirus Disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the clinical and paraclinical markers in these patients. Materials and Methods: The study sample comprised 205 confirmed hospitalized patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted. The patients grouped into 5 based on their IL-6 levels. Then, they were compared with regard to their need for mechanical ventilator and clinical laboratory routine tests. Results: IL-6 levels were significantly higher in hospitalized patients compared with healthy individuals (P<0.001). The IL-6 level was approximately 10-fold of the normal range in 22.9% of the patients. Also, more than 56.1% of them signify IL-6 over 3-fold of the normal range. IL-6

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