Association of CREB1 (rs2253206) and BDNF (rs6265) Polymorphisms with Implementation Intentions Treatment Response in Smoking Reduction
نویسندگان
1 Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Psychiatry School of Medicine, Roozbeh Psychiatry Hospital Tehran University of Medical Sciences, Tehran, Iran
3 Research Center for Cognitive and Behavioral Sciences, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
10.34172/ahj.1502چکیده
Background: Previous studies have shown that implementation intentions are moderately effective in reducing smoking amongsmokers, but the factors determining its effectiveness are unclear. CREB1 (rs2253206) and BDNF (rs6265) polymorphisms havebeen proposed as the genes involved in addictive behaviors; therefore, we investigated their association with smokers’ responsesto implementation intentions psychotherapy.Methods: This clinical trial was conducted on smoking male students at Tehran University and Shahid Beheshti University.The research sample was 78 smoking students who smoked at least seven cigarettes weekly. All of the participants received animplementation intentions intervention session. Their smoking rates were measured before and after the intervention, and allof them were genotyped for CREB1 (rs2253206) and BDNF (rs6265) using PCR-RFLP. The prospective-retrospective memoryquestionnaire (PRMQ) was used to evaluate the prospective memory (PM). Analysis of covariance (ANCOVA) and simple linearregression were used to analyze the data using SPSS version 26 at a significance level of 0.05.Results: The results showed that implementation intentions affect smoking reduction (t = 4.44, P = 0.001). Data analysis showedno relationship between these two SNPs and treatment response. Also, no association was observed between these SNPs and PM.However, regression analysis showed that PM could predict the response to treatment (R2 = 0.10, F = 12.15, P = 0.001).Conclusion: Implementation intentions can be suitable for reducing smoking. Studying the effect of genetic factors onpsychotherapy in larger samples could be an effective way to individualize psychological treatments in reducing smoking,including implementation intentions.
