HIV infection presenting as bone marrow cryptococcosis

نویسندگان
Dharwadkar, Arpana ID 1
Vimal, Shruti ID 2
Buch, Archana C ID 3
Panicker, NK ID 4

1 Department of Pathology, Pad Dr DY Patil Medical College, Pune, Maharashtra, India

2 Department of Pathology, Pad Dr DY Patil Medical College, Pune, Maharashtra, India

3 Department of Pathology, Pad Dr DY Patil Medical College, Pune, Maharashtra, India

4 Department of Pathology, Pad Dr DY Patil Medical College, Pune, Maharashtra, India

doi
چکیده

Disseminated cryptococcal infection is an uncommon initial manifestation in immunocompromised patients. We report a rare case of a 40-year-old female presenting with fever and burning epigastrium. Peripheral blood film revealed a leukoerythroblastic picture with thrombocytopenia. Bone marrow aspiration showed granulomas along with cryptococcal yeast forms. The ELISA test for detection of human immunodeficiency virus (HIV) antigen was positive. Disseminated cryptococcosis can develop as the first manifestation of HIV infection in previously healthy individuals and granulomas in such bone marrow aspiration smears are a valuable clue to an underlying opportunistic infection.

کلیدواژه‌ها
bone marrow, cryptococcus, Granuloma, immunosuppression