Effect of Exercise-Based Interventions on HbA1c in Adults with Type 1 Diabetes: A Systematic Review and Meta-Analysis
نویسندگان
1 Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran
2 Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran
3 Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran
4 Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran
5 Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran
6 Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran
7 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
doi
10.22074/cellj.2025.2050534.1775چکیده
Objective: This study intends to determine whether exercise-based interventions improve haemoglobin A1c (HbA1c)levels in adults with type 1 diabetes (T1D) and examines how different types of exercise influence this association.Materials and Methods: A search of the appropriate electronic databases revealed 18 eligible studies from initial 685records. The effect of exercise training on HbA1c was examined in two parts: i. Exercise training intervention comparedto a T1D control group (between-group analysis) and ii. Pre/post comparison of exercise training intervention on T1Dpatients (within-group analysis).Results: The between-group results showed that exercise training had a statistically significant reduction in HbA1c[mean difference (MD), confidence interval (CI)]: -0.39 (-0.64, -0.15), P=0.002, I2=0%). Subgroup analysis based onthe types of exercise training showed a statistically significant effect of high-intensity interval training (HIIT) on HbA1clevels in both the within-group analyses [MD: -0.24 (-0.45, -0.02), P=0.03, I2=0%] and between-group analyses [MD:-0.39 (-0.64, -0.15), P=0.002, I2=0%].Conclusion: The meta-analysis and meta-regression results suggest that HIIT may be a supportive intervention in T1Dpatients; however, there was insufficient evidence to confirm these findings. Data from more randomised controlled trials(RCTs) are needed to compare the effect of different types of exercise on HbA1c levels in T1D patients [registration:PROSPERO (CRD42023414580)].
