Healthy Male Individuals Possess Higher Plasma HER-2 Level than Females
نویسندگان
1 R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran
2 R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran
3 Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
5 R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran
6 Department of Microbiology, School of Biology, University College of Science, University of Tehran, Tehran, Iran
7 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8 Breast Diseases Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
9 Breast Diseases Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
doi
10.22074/cellj.2022.562589.1134چکیده
Considering HER2 as one of the well-known biomarkers in the cancer field, and published articles regarding serumlevels of HER2, in this paper we tried to highlight the issue that most studies don’t stratify the HER-2 concentrationof individuals in terms of gender. In this brief survey, healthy individuals with no prior non-communicable diseaseswere categorized as males (n=34) and females (n=43), and all samples were evaluated for plasma HER-2 levelsat once. Surprisingly, the plasma level of HER-2 of healthy male individuals (mean= 2.28 ± 0.21 ng/mL) wassignificantly (P<0.0001) higher than the plasma level of HER-2 of healthy females (mean: 0.06 ± 0.09 ng/mL),with no overlap. Therefore, we suggest that more studies are required to re-check the cutoff values for HER-2plasma levels based on gender since the clinical implications of a unique HER-2 cutoff for both genders may beseriously concerning.
