Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis Patients, Single-Center, Prospective, Open-Label, Single-Arm Clinical Trial, Long-Term Follow-up

نویسندگان
Nabavi, Seyed Massood ID 1
Karimi, Shahedeh Karimi ID 2
Sanjari, Leila ID 3
Ghaheri, Azadeh ID 4
Hosseini, Seyedeh-Esmat ID 5
Aghdami, Nasser ID 6
Arab, Leila ID 7
Mardpour, Soura ID 8
Azimian, Vajiheh ID 9
Jarughi, Neda ID 10
Vosough, Massoud ID 11

1 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

2 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

3 International Medicine Department, Mostafa Khomeini Medical Center, Shahed University, Tehran, Iran

4 4Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

5 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran;5Nursing Care Research Center, School of Nursing and Midwifery, Iran University of Med

6 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

7 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

8 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

9 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran;Core Research Facilities (CRF), Isfahan University of Medical Sciences, Isfahan, Iran

10 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

11 Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

doi
10.22074/cellj.2021.7984
چکیده

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with very limited treatment options. Stem cells have been raised as a new treatment modality for these patients. We have designed a single-center, prospective, open-label, and single arm clinical trial to assess the safety, feasibility, and rather efficacy of administrating allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs) in ALS patients. We enrolled 17 patients with confirmed ALS diagnosis with ALS Functional Rating Scale-Revised (ALSFRS-R) (

کلیدواژه‌ها
Allogeneic Cells, Amyotrophic Lateral Sclerosis, Autologous Cell Transplantation, Mesenchymal Stromal Cells, Stem cells