فهرست نشریات علمی دسترسی آزاد ایران

Microalgae are currently used as an important source of valuable natural biologically active molecules in cancer research. The effect of the fractions of Gracilaria salicornia, Padina boergesenii, and Polycladia myrica was evaluated on human melanoma. Cell proliferation and viability were assessed in human malignant melanoma cell lines (A375) and immortalized human foreskin fibroblast (Hu02-KP) through applying ELISA and MTT assays. Seaweed samples were collected from the Persian Gulf (55' 57˚E and 26' 56˚N) at the intertidal zone of Qeshm island coast, Iran. The samples were extracted with EtOH from fresh algae and separated on a chromatography column. A total of 14 fractions were extracted, G. salicornia (G1, G2, G3), P. myrica (F1, F2, F3, F4), and P. boergoseni (P1, P2, P3, P4). 22 components were detected in the fractions by GC-MS. The survival of all fractions (after completely removing EtOH from fractions) was assayed on A375 and Hu02-KP cell lines. The survival of melanoma cell A375 was determined 41-58% in the fraction of G3, G. salicornia, although no significant toxicity was observed on fibroblast Hu02-KP. Furthermore, the fraction P3 of P. boergesenii had more than 85% mortality in melanoma cell line A375 and no significant toxicity was observed on fibroblast Hu02-KP. Finally, 1, 2-benzenedicarboxylic acid, diisooctyl ester and hexadecanoic acid, methyl ester was respectively detected as the most abundant components in P. boergoseni and G. salicornia. In conclusion, Algae have the potential to extract complex substances that may be beneficial in healthcare; however, additional research is needed to confirm the efficacy and safety of algae-derived compounds for cancer treatment.