فهرست نشریات علمی دسترسی آزاد ایران

Recently, with great interest we read the published article by Beladi Mousavi et al entitled “The protective effect of hydration with Isotonic Saline, KCl and MgSo4 in Cisplatin nephrotoxicity" in your most valuable journal (1).The author evaluated the possible effect of hydration with isotonic saline, KCl and MgSo4 in prevention of cisplatin nephrotoxicity among patients with various malignancies who were received cisplatin at a dosage of at least 50 mg/m2 combined with other chemotherapy agent. According to the results of the study, the prevalence of cisplatin-induced renal impairment has decreased and hydration with isotonic saline has a protective effect against cisplatin nephrotoxicity (1).Cisplatin is a potent antineoplastic agent which is currently used in the treatment of broad spectrum of malignancies. However the use of cisplatin is limited because of cisplatin nephrotoxicity which can be progressive in significant percent of patients (2,3).The most important clinical manifestation of cisplatin nephrotoxicity is acute and chronic renal impairment which can be associated with significant morbidity and mortality among these patients (4-10).Hypomagnesaemia, hypokalemia, salt wasting, Falconry syndrome and thrombotic microangiopathy with features of the hemolytic-uremic syndrome or thrombotic thrombocytopenic purpura are other manifestation of cisplatin nephrotoxicity which are also occurred in significant percent of cases (11).Therefore, measures for prevention of cisplatin-induced renal impairment must be used in all of patients who are candidates for cisplatin administration