Dorema kopetdaghense Pimenov: A potent antifungal medicinal plant
نویسندگان
1 Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, SE, 75007, Uppsala, Sweden
4 Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
6 Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
7 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
doi
10.22034/cmm.2024.345183.1499چکیده
Background and Purpose: Dorema species are well-known antifungal medicinal plants. Dorema kopetdaghense (Apiaceae family) is a rarely investigated plant endemic to Iran. The present study aimed to assess the antifungal, antibacterial, antioxidant, and cytotoxic activities of root extracts of different plants.Materials and Methods: The methanolic crude extract (MeOH) and its sub-fractions, including petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAc), and nbutanol (n-BuOH) were prepared.Results: Results from the antifungal and antibacterial activities of fractions indicated remarkable antifungal effects against Candida albicans with minimum inhibitory concentration and minimum bactericidal concentration values of 10 µg/mL; however, no cytotoxicity was observed in the case of selected cancer cells. Moreover, methanolic soluble fractions showed good antiradical effects evaluated via DPPH and β-carotene bleaching tests possessing half-maximal inhibitory concentration (IC50) of 20.11 and 41.32 µg/mL, respectively, though it was less effective than positive controls ascorbic acid (8.47 and 31.71 µg/mL, respectively) and butylated hydroxytoluene (IC50: 10.29 and 33.55 µg/mL, respectively).Conclusion: It can be concluded that strong antifungal and antioxidant activities without notable cytotoxicity, suggest the potential safety of the plant to be used as a natural antifungal remedy as well as a preservative in the food industry.
