Clinical, epidemiological, and mycological features of patients with candidemia: Experience in two tertiary referral centers in Iran
نویسندگان
1 Research center for antibiotic stewardship and antimicrobial resistance, Department of infectious diseases and Tropical Medicine, Imam Khomeini
2 Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Infectious Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
6 Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
7 Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
8 Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain
9 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
10 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
11 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
12 Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
13 Clinical Laboratory, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
14 Department of Biostatistics and Epidemiology, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
15 Department of Chemistry and Biology, Ryerson University, Toronto, Canada
16 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
doi
10.18502/cmm.8.3.11207چکیده
Background and purpose: Candidemia is a major cause of morbidity and mortality among patients receiving immunosuppressive therapy and those hospitalized with serious underlying diseases. Here, we investigated the epidemiological, clinical and mycological features of candiemia in Tehran, Iran.Material and methods: A prospective observational study of all patients diagnosed with candidemia was performed at two referral teaching hospitals in Tehran, Iran between February to December 2018. Demographic characteristics, underlying diseases, risk factors, clinical symptoms, and laboratory analyses of candidemic patients with positive culture were mined. Candida isolates were molecularly identified by sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). The antifungal susceptibility testing for fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, caspofungin, micafungin and anidulafungin against the isolates were performed using CLSI broth microdilution reference method (M27-A3).Results: A total of 89 episodes were identified, with an incidence of 2.1 episodes/1000 admissions. The most common underlying disease was sepsis (48%) followed by malignancy (46%), renal failure/dialysis (44%), and hypertension (40%). The overall crude mortality was 47%. C. albicans (44%) was the most frequent causative agent followed by C. glabrata (21%), C. parapsilosis complex (15%), C. tropicalis (11%), and C. lusitaniae (3.5%). All the isolates were susceptible to amphotericin B. The activity of all the four azoles was low against non-albicans Candida species, especially C. tropicalis.Conclusion: Increase in non-albicans Candida species with reduced susceptibility to antifungal drugs might be alarming in high-risk patients. Therefore, accurate knowledge of predisposing factors and epidemiological patterns in candidemia are effective steps for managing and decreasing the mortality rate in candidemia.
