Fatal pulmonary Scedosporium aurantiacum infection in a patient after near-drowning: A case report
نویسندگان
1 Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
2 Invasive Fungi Research Centre (IFRC), Mazandaran University of Medical Sciences, Sari, Iran
3 Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
4 Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5 Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
6 Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
7 Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
8 Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
9 Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
doi
10.18502/cmm.7.4.8410چکیده
Background and Purpose: Scedosporium spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.Case report: Herein, we report a fatal case of pulmonary infection caused by Scedosporium species associated with a car crash and near-drowning in a sewage canal.Scedosporium aurantiacum isolated from bronchoalveolar lavage was identified by PCR-sequencing of β-tubulin genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.Conclusion: This report, as the first case of pulmonary scedosporiosis after near-drowningin Iran, highlights the importance of high suspicion in near-drowning victims, promptidentification of Scedosporium spp., and early initiation of appropriate antifungal therapy.
