فهرست نشریات علمی دسترسی آزاد ایران

Background: Filler-induced facial skin ischemia is a potential complication of dermal filler injections that can result in tissue damage and necrosis. Due to its vasodilatory properties, nitroglycerin has been proposed as a treatment option; however, its effectiveness in this context remains uncertain.Method: A narrative review was conducted to investigate the existing evidence on the effectiveness of nitroglycerin in treating filler-induced facial skin ischemia. Relevant studies were identified through searches of electronic databases and manual screening of reference lists.Results: findings demonstrated limited evidence supporting the efficacy of the nitroglycerin in this context. Although there are case studies indicate that the combination of nitroglycerin and hyaluronidase effectively treats filler-induced facial skin ischemia, only one case report demonstrates the efficacy of nitroglycerin alone. Furthermore, a rat model showed no benefits from nitroglycerin and revealed harmful results.Conclusion: The evidence regarding the efficacy of nitroglycerin in treating filler-induced facial skin ischemia is inconclusive, which calls into question its routine use. Further studies are needed to ascertain the efficacy of nitroglycerin both as a standalone treatment and in combination with other therapies for this condition. Clinicians should consider the limited available data when selecting treatment options for individuals with filler-induced facial skin ischemia.