فهرست نشریات علمی دسترسی آزاد ایران

Background: Autoimmune blistering diseases (AIBDs) are rare and potentially life-threatening conditions that are often associated with various bacterial infections. This study aimed to assess the prevalence of bacterial skin infections and their association with other risk factors in patients with infected AIBDs. Methods: This study was conducted on 47 patients with AIBDs. Two swabs for bacterial culture were obtained from each patient: one from wound secretions and the other from the nose. To determine the association between bacterial infections and other risk factors, patient information—including demographic data, AIBD types, hospitalization details, medical history, symptoms, and medications—was collected. Results: Pemphigus vulgaris and bullous pemphigoid were identified as the most common immunobullous diseases, with prevalences of 61.7% and 25.6%, respectively. Twenty-three of 47 patients (48.9%) were found to be nasal carriers of Staphylococcus aureus, with the predominant strain being methicillin-susceptible Staphylococcus aureus (MSSA) at 42.6%. Bacterial skin infections were detected in 72.3% of patients, of whom 59.6% had infections at the time of admission, while 12.7% acquired nosocomial infections. Conclusion: MSSA was the most frequently isolated bacterial strain from wound secretions, followed by methicillin-resistant Staphylococcus aureus (MRSA) and Klebsiella pneumoniae. Most MSSA and MRSA isolates exhibited resistance to erythromycin and clindamycin. No significant association was found between the incidence of bacterial infections and the severity of AIBDs, comorbidities, immunosuppressive medication use, or the duration and frequency of hospitalizations.