فهرست نشریات علمی دسترسی آزاد ایران

Background: Lichen planus (LP) is a chronic inflammatory mucocutaneous disorder increasingly associated with systemic metabolic abnormalities, particularly dyslipidemia. Emerging evidence suggests that chronic inflammation in LP may alter lipid metabolism, thereby contributing to an elevated cardiovascular risk profile. This study aimed to evaluate changes in lipid profiles across different clinical variants and durations of LP, with a focus on identifying patterns associated with disease distribution, severity, and metabolic risk.   Methods: A cross-sectional study was conducted over six months at Al-Kindy teaching hospital involving 64 adult patients clinically diagnosed with LP. Demographic data, disease characteristics, and lipid profiles—including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)—were collected. Patients were stratified according to LP subtype, BMI, and disease duration. Results: LP patients with a disease duration >12 months exhibited significantly elevated TC (213.92 ± 26.41 mg/dL) and TG (166.23 ± 30.78 mg/dL). A biphasic pattern in HDL was observed, with the lowest levels during 6–12 months of disease (P = 0.005). The oral and cutaneous subtype demonstrated the highest mean cholesterol, while the oral and genital subtype exhibited the highest triglycerides. Significant associations were found between BMI and LP subtype (P = 0.008), with obese patients showing a higher prevalence of multisite involvement. Conclusion: LP, particularly in its chronic and multisite forms, is associated with dysregulated lipid metabolism. These findings underscore the importance routine metabolic screening in LP patients to prevent long-term cardiovascular complications.