Extensive lupus vulgaris: a case report with unusual clinical and laboratory diagnostic profiles
نویسندگان
1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt
3 Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
4 Department of Clinical Pathology, Faculty of Medicine, New Valley University, New Valley, Egypt
5 Faculty of Biotechnology, Badr University in Assiut, Assiut, Egypt
6 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt
doi
10.22034/ijd.2024.434303.1804چکیده
The human immunodeficiency virus (HIV) pandemic has been associated with increased resistance against mycobacterium tuberculosis (MTB), leading to the reemergence of tuberculosis (TB) and posing a significant public health threat, particularly in developing countries. According to the World Health Organization (WHO), TB is the ninth leading cause of death worldwide and the leading cause of death from a single infectious agent. Lupus vulgaris (LV), the most common type of cutaneous tuberculosis, is considered a great imitator in dermatology due to its diverse clinical presentations, including nodular, papular, plaque, ulcerative, tumor-like, and psoriasiform lesions. Additionally, laboratory investigations LV often have low sensitivity and specificity, complicating diagnosis. The complex nature of its clinical presentations and diagnostic challenges frequently result in delayed diagnosis. Moreover, untreated lesions tend to progress, leading to scarring, contractures, and tissue destruction. Here, we present an unusual case of extensive LV with multiple negative investigations except for a positive GeneXpert MTB/RIF assay. We report this case to highlight and analyze various diagnostic modalities for LV to prevent delayed management.
