فهرست نشریات علمی دسترسی آزاد ایران

Cutaneous mastocytosis (CM)is a rare disorder characterized by abnormal accumulation of mast cells within the skin. Although it most commonly presents in childhood, adult-onset cases are less frequent and often associated with systemic involvement. The clinical presentation can vary, which can make diagnosis challenging without histopathologic confirmation. A 43-year-old male presented with a 6-year history of progressive, pruritic, reddish-brown truncal plaques and papules, which were exacerbated by spicy foods and stress. Physical examination revealed no systemic involvement, and laboratory tests were unremarkable. Histopathological examination confirmed the diagnosis of cutaneous mastocytosis.Treatment included a combination of fexofenadine, montelukast, a topical compound ointment, and phototherapy. After two months of therapy, the patient reported significant relief from pruritus and moderate improvement in the appearance of the skin lesions. This case highlights the critical role of histopathologic evaluation in establishing the diagnosis of adult-onset CM and demonstrates the potential benefits of a multimodal therapeutic approach in symptom management and lesion control.