فهرست نشریات علمی دسترسی آزاد ایران

Wells syndrome, also known as eosinophilic cellulitis, is a rare skin disorder characterized by recurrent inflammatory erythematous eruptions associated with eosinophilia. Histopathological examination reveals dermal eosinophilic infiltration. We report a case involving a 44-year-old female patient who presented with recurrent erythematous plaques on the left flank and lower limbs for six months. Recently, she experienced moderate to severe pain on the posterior surface of the right shin at the site of one of her cellulitis-like lesions, which was diagnosed as deep vein thrombosis through a color Doppler ultrasound examination. The skin lesions were refractory to various treatments, including corticosteroids and antihistamines. The patient was subsequently treated with a course of oral cyclosporine (100 mg daily), which successfully resolved her symptoms within a few days, with no observed side effects. This case report suggests that low-dose cyclosporine may be a safe and effective therapeutic option for patients with Wells syndrome.