فهرست نشریات علمی دسترسی آزاد ایران

Epidermodysplasia verruciformis (EV) is a rare hereditary condition characterized by an increased susceptibility to infections caused by specific human papillomaviruses (HPVs), resulting from an impaired cell-mediated immune response. HPV infection can lead to the development of warty lesions, pityriasis versicolor-like spots, and an elevated risk of skin cancer, particularly Bowen’s disease and squamous cell carcinoma. The most favorable outcomes for individuals with EV can be achieved through early diagnosis and treatment. In this report, we present a 16-year-old female patient who exhibited asymptomatic pityriasis versicolor-like lesions on her neck, chest, back, and extremities. Physical examination revealed multiple yellowish-gray papules and plaques with well-defined borders. Evaluation of the hair, mucous membranes, and nails, along with other systemic examinations, showed no abnormalities. A skin biopsy confirmed the diagnosis of EV, and the patient was prescribed isotretinoin, along with sunscreen and regular dermatological check-ups. By enhancing awareness and understanding of this rare genetic disorder, healthcare professionals can improve the quality of life for affected individuals and mitigate their risk of developing malignancies.