فهرست نشریات علمی دسترسی آزاد ایران

Background: The surgical treatment of vitiligo becomes essential in cases where there is a delayed therapeutic response to medical treatment or a complete lack of response, particularly in acral areas. The need for phototherapy following surgical interventions for vitiligo is a subject of debate.Methods: Patients with a clinical diagnosis of acral vitiligo were enrolled in this investigator-blind, randomized clinical trial. The patients underwent suction blister epidermal grafting (SBEG) on both sides. The lesions on only one side were randomized to receive topical psoralen plus ultraviolet A (PUVA) phototherapy. The therapeutic response on both sides was evaluated using the reverse Vitiligo Area Severity Index (VASI) score, and Vitiligo Extent Score for a Target Area (VESTA) at the first, second, fourth, and sixth months following SBEG. Additionally, we measured the repigmentation rate, patient satisfaction, and quality of life.Results: Fifteen patients were enrolled in the study. The reverse VASI and VESTA scores decreased significantly on both sides after treatment (P < 0.001). The improvements in reverse VASI and VESTA scores were not significantly different between the sides (P = 0.703 and P = 0.910, respectively). The time to achieve 50% repigmentation did not differ between the sides (P = 0.915). Patients reported greater satisfaction with the color of the lesion following phototherapy compared to SBEG alone (P = 0.01). Treatment for acral vitiligo significantly improved the quality of life for the patients (P < 0.001).Conclusion: SBEG is an effective treatment for acral vitiligo. The addition of PUVA phototherapy following SBEG does not significantly enhance the clinical response and can therefore be omitted from the therapeutic protocol.