18F-FDG PET/CT usefulness vs Tc99m-Tetrofosmin in the assessment of malignant brain gliomas: Report of two cases
نویسندگان
1 Pathological Anatomy Unit, University of Bari “Aldo Moro”, Bari, Italy
2 Nuclear Medicine Unit, University of Bari “Aldo Moro”, Bari, Italy
3 Nuclear Medicine Unit, University of Bari “Aldo Moro”, Bari, Italy
4 Nuclear Medicine Unit, University of Bari “Aldo Moro”, Bari, Italy
5 Nuclear Medicine Unit, University of Bari “Aldo Moro”, Bari, Italy
6 Nuclear Medicine Unit, University of Bari “Aldo Moro”, Bari, Italy
doi
چکیده
Gliomas account for almost 80% of primary malignant brain tumors in adults. Magnetic Resonance imaging (MRI) is still the gold standard for diagnosis of brain tumors and brain 99mTc-tetrofosmin Single Photon Emission Computed Tomography (99mTc-tetrofosmin-SPECT) has been established as a useful tool for their evaluation. Fluorine-18–2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) provides non-invasive information for staging, clinical assessment and prognosis of glial tumors. We report 2 cases of patients with brain lesions described on MRI suspected for malignancy, however 99mTc-tetrofosmin-SPECT that didn’t show any lesion, 18F-FDG PET/CT revealed radiotracer uptake that supported the hypothesis of malignant gliomas, confirmed later by biopsy. Our cases confirm 18F-FDG PET/CTmay be useful for differentiating common enhancing malignant brain tumors and is recommended when differential diagnoses are difficult to narrow using MRI and 99mTc-tetrofosmin-SPECT. 18F-FDG PET/CT can be used to characterize their aggressiveness and to detect a more feasible site for a stereotaxic biopsy. It yields supplementary non-invasive information to conventional imaging useful in the clinical decision-making.
