Accuracy of modification of diet for renal disease and Cockcroft-Gault equations as compared to the radioisotope double sample method: A study in patients with acute renal failure
نویسندگان
1 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Nuclear Medicine, Vali-asr Hospital Tehran University of Medical Sciences, Tehran, Iran
5 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
6 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
7 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
8 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
9 Department of Nephrology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
10 Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
چکیده
Introduction: We intended to assess the accuracy of re-expressed Modification of Diet for Renal Disease (MDRD) and Cockcroft-Gault (CG) equations to estimate glomerular filtration rate (GFR) in chronic kidney disease in two different etiologies of acute renal failure (ARF): acute tubular necrosis (ATN) and acute glomerulonephritis (AGN). Methods: Patients admitted for ARF or the patients complicated with ARF during the course of their hospitalization were enrolled to the study (n=21; 14 females and 7 males; 11 ATN and 12 AGN). When the plasma creatinine reached a steady state (DPSM) using 99mTc-DTPA. GFR was also estimated by MDRD (GFRMDRD) and CG (GFRCG) equations. Results: The patients aged 44.8±19.5 years and weighted 67.8±10.7kg. GFRDPSM (32.9±14.7 ml/min) was statistically different from the GFRMDRD (11.6±8.2 ml/min; pCG was lower than GFRDPSM in patients with either ATN (16.5±12.5ml/min and pDPSM and GFRMDRD (r=0.34; p=0.13) but GFRDPSM and GFRCG values were correlated (r=0.48; p=0.03). Out of subjects with GFRDPSM >30, 92.3% had GFRMDRDCG Conclusion: Our results indicate that MDRD and CG equations were substantially inaccurate in patients with ARF. More precise methods of GFR evaluation is recommended in these patients.
