Omega 3-Induced Autophagy: A Two-Sided Sword in Cell Death from Historical Perspective in Clinical Application and Biological Mechanisms
نویسندگان
1 Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2 Geriatric Department, Ziayian Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
doi
10.30476/ijns.2025.104987.1379چکیده
Omega-3 fatty acids, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA), are polyunsaturated fatty acids (PUFAs) with numerous health benefits. They play a critical role in various cellular functions, such as maintaining cell membrane integrity, cellular signaling pathways, and cell-to-cell communication. Omega-3s are known for their anti-inflammatory, anti-cancer, anti-depressant, and lipid-lowering properties. Autophagy, a cellular process responsible for recycling and degrading cellularcomponents, is closely linked to these fatty acids. The impact of omega-3 fatty acids on autophagy signaling pathways hold promise for innovative therapeutic strategies in disease management and overall well-being. This review explores the influence of omega-3 fatty acids on autophagy and provides insights into the potential mechanisms involved.
