فهرست نشریات علمی دسترسی آزاد ایران

‎Drug repurposing presents a cost-effective and time-efficient alternative to traditional drug discovery by identifying new therapeutic uses for existing medications‎. ‎As biomedical data grows in scale and complexity‎, ‎there is an increasing demand for predictive models that balance accuracy‎, ‎interpretability‎, ‎and computational efficiency‎. ‎In this study‎, ‎we systematically evaluate hybrid models that combine established matrix factorization techniques with machine learning regressors‎, ‎with an emphasis on interpretable and lightweight models such as the Decision Tree Regressor‎. ‎Using the widely adopted Fdataset‎, ‎comprising 1,933 known associations between 593 drugs and 313 diseases‎, ‎we demonstrate that several of these hybrid approaches achieve predictive performance comparable to or surpassing that of complex models like WNMFDDA‎, ‎while significantly reducing memory usage and training time‎. ‎Notably‎, ‎our framework relies solely on the drug–disease association matrix‎, ‎removing the dependency on auxiliary similarity data‎, ‎which is often unavailable in real-world applications‎. ‎Among the tested models‎, ‎the NMF DecisionTreeRegressor offers the highest accuracy‎, ‎making it ideal for accuracy-critical scenarios‎, ‎while the Ridge model stands out for its efficiency and suitability for resource-constrained environments‎. ‎To enhance transparency‎, ‎we further apply LIME (Local Interpretable Model-Agnostic Explanations) to provide interpretable insights into model predictions‎. ‎These findings highlight a practical and scalable framework for drug repurposing‎, ‎particularly suited for environments with limited computational resources‎. ‎Our approach supports the development of accessible‎, ‎data-driven predictive tools that accelerate the transition from computational modeling to clinical application‎.