Novel Three-Step Synthesis of Imidazo[1,2-c]quinazoline-5(6H)-thione Derivatives
نویسندگان
1 Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Islamic Republic of Iran
2 Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Islamic Republic of Iran
doi
10.22059/jsciences.2018.64790چکیده
A novel synthesis of Iimidazo[1,2-c]quinazoline-5(6H)-thione framework was developed through a three-step reaction starting from benzil. The resulting (2-nitrophenyl)-4,5-diphenyl-1H-imidazole from the reaction of benzil and different 2-nitrobenzaldehyde, reduction of nitro group and then cyclization reaction with carbon disulfide (CS2). All steps were carried out under easy and user-friendly conditions in short time without using expensive catalysts or reagents.
