An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System

نویسندگان
Pouramiri, B. ID 1
Tavakolinejad Kermany, E. ID 2
Khajesamani, H. ID 3
Khabazzadeh, H. ID 4

1 Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of Iran

2 Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of Iran

3 Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of Iran

4 Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of Iran

doi
چکیده

An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green chemistry catalyst system under solvent-free conditions described. Compared with the classicalBiginelli reaction conditions, this method has the advantages of good to excellent yields (80-99%) and short reaction time.

کلیدواژه‌ها
Dihydropyrimidinones, Lanthanum(III)chloride, Solvent –free, One-pot condensation