فهرست نشریات علمی دسترسی آزاد ایران

Objectives: We investigated the relationships between the vitamin D receptor BsmI (rs1544410) gene polymorphism, serum vitamin D and calcium levels, and the risk of osteoporosis in women aged 40 years and older. Methods: This case-control investigation enrolled participants (30 cases and 30 controls) classified into normal and osteoporotic groups using a dual-energy X-ray absorptiometry (DEXA) scan. Vitamin D and calcium levels were obtained from peripheral blood samples. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the BsmI polymorphism. Differences between groups were analyzed using an analysis of variance (ANOVA) test. Results: 60 individuals (30 cases and 30 age-matched controls) were enrolled. The lumbar and femoral T-scores, as well as calcium levels, were significantly lower in the cases compared to the controls (P < 0.005). Among postmenopausal women, the lumbar T-scores significantly differed between cases with VDR polymorphisms (P = 0.003) and controls (P = 0.001). Among premenopausal women, there was only a significant difference in VDR polymorphisms in the control group (P = 0.006). Calcium and vitamin D levels were significantly different between the VDR polymorphisms in cases and control groups, but only among postmenopausal women (P < 0.005 for all comparisons). No significant differences were observed between the VDR polymorphism in terms of femoral T-scores, neither in the cases nor the controls (P for all > 0.005). Conclusion: This study found no differences in VDR polymorphism between individuals with and without osteoporosis. Additionally, the lumbar T-scores, calcium, and vitamin D levels were significantly different between the VDR polymorphisms in the case and control groups among postmenopausal women.