A Study of Toxification Types in Intubated Poisoned Patients in the ICUs of Taft Shahid Beheshti and Yazd Shahvali Hospitals (2015–2019)
نویسندگان
1 Department of Forensic Medicine & Clinical Toxicology, Yazd Branch, Islamic Azad University, Yazd, Iran
2 Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
3 Department of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
4 General Practitioner, Social security organization of Yazd, Iran
5 Department of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
6 Department of Internal medicine, Fasa University of Medical Sciences, Fasa, Iran
7 Department of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
8 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
9 Department of Internal medicine, Faculty of medicine, Shahid Sadougi University of Medical Sciences and Health Service, Yazd, Iran
doi
10.30483/rijm.2025.254503.1308چکیده
Background: Although poisoning is one of the most common reasons for visits to emergency departments, the types of toxification among intubated poisoned patients in ICUs have not been well documented. Objectives: This study aimed to identify the toxification types among intubated poisoned patients in an intensive care unit (ICU). Methods: This retrospective cross-sectional study was conducted on poisoned patients with chemical compounds, hospitalized in ICU, and underwent endotracheal intubation. Toxicological and clinical factors, as well as outcomes, were collected and analyzed. Analysis was performed using the Chi-square test and Fisher's exact test. The p-value < 0.05 was considered significant. Results: In this study, 307 patients with the diagnosis of poisoning were evaluated. The most common toxic agents were methadone (46.8%), opium (5.9%), organophosphorus compounds (5.9%), methanol (4.2%), and other chemical substances (2.4%). A single compound poisoned most patients (70%). Furthermore, 167 patients (54.4%) experienced accidental poisoning or drug abuse, while the remaining cases (45.6%) were due to suicidal intentions. Significant differences were observed between these two groups (suicidal and accidental poisoning groups) regarding age, gender, types of toxification, and grouping and duration of ICU hospitalization (P < 0.05). Significant differences were found in patient outcomes based on toxification types, toxification type grouping, or ICU hospitalization duration (P < 0.05). Conclusion: Our results indicate that opioids, especially methadone, were the most frequent cause of poisoning in our study. Pesticide poisoning occurred significantly more often in patients with suicidal intent. Additionally, patient outcomes were significantly influenced by age, gender, type, grouping of toxic agents, and duration of ICU hospitalization.
