فهرست نشریات علمی دسترسی آزاد ایران

The use of accelerated temperature stability studies using the Arrhenius relationship is routine for estimating the stability of a drug at room temperature. Therefore, the acceleration method is used to determine the expiration date of dexamethasone aqueous formulation manufactured in Iran. A high-performance liquid chromatography (HPLC) method utilizing ultraviolet (UV) detection for dexamethasone disodium phosphate and ophthalmic solution is described. Using the kinetic information generated from the high-temperature studies, at 60,70, 80 and 90°C, an Arrhenius plot for dexamethasone disodium phosphate degradation was constructed and the shelf-life of the drug was estimated