Synthesis of Pyridopyrimidine-Indole Hybrids Using γ-Fe2O3@HAp@PBABMD@Cu as Efficient Magnetic Nanocatalyst

نویسندگان
طاهرسلطانی فروغ ID 1
مهدوی نجم آبادی زهرا ID 2
حکیمنیا محمود ID 3
تفرجی اسماء ID 4

1 دانشگاه آزاد اسلامی

2 دانشگاه آزاد اسلامی

3 دانشگاه علامه طباطبایی

4 دانشگاه شیراز

doi
10.22036/org.chem.2022.316963.1268
چکیده

A novel and practical method for the synthesis of pyridopyrimidine-indole hybrids, using a three-component reaction of thiouracil or 6-amino-N,N-dimethyluracil, various aryl aldehydes and 3-cyanoacetyl indole in the presence of a green heterogeneous nano-catalyst γ-Fe2O3@HAp@PBABMD@Cu was developed. This protocol furnished the desired products in high yields (82-95%) and lower reaction times (18-40 min).

کلیدواژه‌ها
Pyridopyrimidine, 3-Cyanoacetylindole, 6-Amino-N, N-dimethyluracil, Aanocatalyst, γ-Fe2O3@HAp@PBABMD@Cu